Product Overview
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Ask ChatGPT: What is SS31 Elamipretide good for?
BamaMax™ presents premium-grade SS-31 (Elematide), a synthetic tetrapeptide specifically designed for in vitro laboratory evaluation and biochemical research. This cell-permeable compound acts as a powerful molecular tool for investigators exploring mitochondrial energetics, oxidative stress pathways, and cardiolipin stabilization. Supplied as a highly stable, white lyophilized powder in a sealed glass research vial, our SS-31 ensures optimal structural integrity and long-term storage compatibility for precise experimental design.
Product Overview & Mechanism
SS-31 (Elematide) is a uniquely engineered peptide featuring an alternating aromatic-cationic structural motif (D-Arg-Dmt-Lys-Phe-NH₂). This specialized sequence enables the peptide to freely penetrate cell membranes and selectively accumulate within the inner mitochondrial membrane (IMM) independent of mitochondrial membrane potential.
The primary mechanism of SS-31 centers on its high-affinity binding to cardiolipin, a signature phospholipid exclusively localized to the IMM. By structurally interacting with cardiolipin, SS-31 prevents its oxidation, stabilizes mitochondrial cristae structures, and optimizes the electron transport chain. In models of cellular stress, this stabilization directly mitigates the overproduction of reactive oxygen species (ROS) and prevents the induction of the mitochondrial permeability transition pore (mPTP), thereby protecting cellular respiration and ATP production.
Technical Specifications
| Attribute | Specification Details |
|---|---|
| Product Name | SS-31 (Elematide) |
| Synonyms | Elamipretide, Bendavia, MTP-131 |
| Molecular Formula | C₃₂H₄₉N₉O₅ |
| Molecular Weight | 639.80 Da |
| Sequence | D-Arg-Dmt-Lys-Phe-NH₂ (Dmt: 2',6'-dimethyltyrosine) |
| Physical Format | White Lyophilized (Freeze-Dried) Powder |
| Purity Grade | ≥99% via HPLC-UV and Mass Spectrometry (MS) |
| Target Location | Inner Mitochondrial Membrane / Cardiolipin Interaction |
| Documentation | Lot-specific Certificate of Analysis (COA) included |
Core Research Applications
- Mitochondrial Energetics: Investigating cellular respiration, oxidative phosphorylation efficiency, and ATP synthesis pathways under metabolic duress.
- Oxidative Stress & ROS Mapping: Quantifying the suppression of mitochondrial-derived reactive oxygen species and downstream cellular lipid peroxidation.
- Ischemia-Reperfusion Models: Modeling tissue survival mechanics, structural cristae preservation, and injury pathways in hypoxic cell cultures.
- Organelle Decay & Longevity Studies: Evaluating the role of mitochondrial integrity in systemic aging models, neurodegenerative pathways, and metabolic dysfunction.
Handling & Storage Guidelines
To preserve maximum biological activity and prevent degradation, follow these sequence-specific storage protocols:
- Long-Term Storage (Dry): Keep the raw, lyophilized powder sealed inside its primary vial and store at -20°C for up to 1 year, or -80°C for extended preservation away from ambient moisture.
- Reconstitution Protocol: Reconstitute using sterile, research-grade solvents, phosphate-buffered saline (PBS), or bacteriostatic water tailored to your specific in vitro assay constraints. Gently swirl the vial to completely dissolve the cake; do not shake vigorously.
- Post-Reconstitution Storage: Store the liquid solution at 2°C to 8°C and utilize within 14 days. For multi-week studies, aliquot the solution immediately into single-use volumes and store at -20°C or lower to prevent destructive freeze-thaw cycles.
LABORATORY RESEARCH USE ONLY: This product is synthesized, distributed, and sold strictly for laboratory research, in vitro testing, and analytical methodologies. SS-31 has not been evaluated or approved by the FDA for human or veterinary applications, clinical diagnostics, therapeutics, or consumer administration. All handling must be conducted by qualified laboratory professionals in controlled scientific environments.
