Product Overview
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BamaMax™ presents premium-grade Sermorelin, a synthetic 29-amino acid peptide specifically designed for in vitro laboratory evaluation and biochemical research. This fully functional truncated analog of endogenous growth hormone-releasing hormone (GHRH) acts as a powerful molecular tool for investigators exploring pituitary somatotroph regulation, growth hormone secretory dynamics, and downstream IGF-1 signaling pathways. Supplied as a highly stable, white lyophilized powder in a sealed glass research vial, our Sermorelin ensures optimal structural integrity and long-term storage compatibility for precise experimental design.
Product Overview & Mechanism
Sermorelin represents the shortest fully active fragment of native GHRH (GHRH 1-29 amide). It retains the exact amino-terminal configuration required to selectively bind and activate the growth hormone-releasing hormone receptor (GHRHR) on the surface of pituitary somatotrophs.
The primary mechanism of Sermorelin centers on stimulating the synthesis and episodic secretion of growth hormone (GH) via a receptor-mediated, adenylate cyclase-dependent pathway. Unlike direct growth hormone introduction, which bypasses regulatory loops, Sermorelin preserves the native pituitary-hypothalamic feedback network, making it an excellent chemical agent for profiling biological feedback mechanisms, tissue-specific insulin-like growth factor 1 (IGF-1) responses, and cellular metabolic signaling cascades under highly controlled experimental parameters.
Technical Specifications
| Attribute | Specification Details |
|---|---|
| Product Name | Sermorelin |
| Synonyms | Sermorelin Acetate, GHRH (1-29) Amide, GRF 1-29 |
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Molecular Weight | 3357.88 Da |
| Sequence Length | 29 Amino Acids |
| Physical Format | White Lyophilized (Freeze-Dried) Powder |
| Purity Grade | ≥99% via HPLC-UV and Mass Spectrometry (MS) |
| Target Axis | GHRH Receptor / Pituitary-Somatotropic Network |
| Documentation | Lot-specific Certificate of Analysis (COA) included |
Core Research Applications
- Pituitary Secretion Dynamics: Investigating the pulsatile release kinetics and signaling pathways of growth hormone within somatotroph cultures.
- IGF-1 Feedback Regulation: Mapping upstream and downstream signaling cascades that dictate the systemic expression of insulin-like growth factor 1.
- Cellular Metabolism & Repair: Modeling the impacts of GHRH receptor activation on cellular proliferation, nitrogen retention, and lipolysis pathways.
- Endocrine Axis Modulation: Evaluating the structural feedback loops and counter-regulatory mechanisms involved in biological age-related somatopause modeling.
Handling & Storage Guidelines
To preserve maximum biological activity and prevent degradation, follow these sequence-specific storage protocols:
- Long-Term Storage (Dry): Keep the raw, lyophilized powder sealed inside its primary vial and store at -20°C for up to 1 year, or -80°C for extended preservation away from ambient moisture.
- Reconstitution Protocol: Reconstitute using sterile, research-grade solvents, 0.9% sterile saline, or bacteriostatic water tailored to your specific in vitro assay constraints. Gently swirl the vial to completely dissolve the cake; do not shake or agitate aggressively.
- Post-Reconstitution Storage: Store the liquid solution at 2°C to 8°C and utilize within 14 days. For multi-week studies, aliquot the solution immediately into single-use volumes and store at -20°C or lower to prevent destructive freeze-thaw cycles.
LABORATORY RESEARCH USE ONLY: This product is synthesized, distributed, and sold strictly for laboratory research, in vitro testing, and analytical methodologies. Sermorelin has not been evaluated or approved by the FDA for human or veterinary applications, clinical diagnostics, therapeutics, or consumer administration. All handling must be conducted by qualified laboratory professionals in controlled scientific environments.
